enzyme activity

• Mitochondrial Dysfunction

Cell-mediated immunity (CMI) response of healthy humans and cancer (Ca) patients to specific tumor antigen and nonspecific (LDV - lactate dehydrogenase virus) antigen, and of acute myocardial infarction (AMI) and schizophrenia (Sch) patients to nonspecific antigen was investigated. Large differences of CMI response of healthy humans in comparison with Ca, AMI, Sch patients were found. CMI response to antigens displays transferred information about cells under immune surveillance. LDV disturbs the oxidative energy production system. We assume that CMI response to LDV antigen monitors pathological states of mitochondrial energy production which results in disturbances of electromagnetic activity of living cells.

... large amount of LDH (lactate dehydrogenase enzyme now clasified as NAD 1.1.1.27 Oxidoreductase) in p...

• Neural Network World; International Journal on Neural and Mass - Parallel Computing and Information Systems
• Band 19 Nr. 4, Juli 2009

• Fröhlich's Coherent Vibrations in Healthy and Cancer Cells

Fröhlich formulated the hypothesis of coherent electrical polar oscillations in biological systems. The hypothesis predicts that generated electromagnetic field with a dominant electric component has a basic role in organization, transport, and interactions inside a cell and among cells. If mitochondria are entirely functional, the cellular cytoskeleton satisfies conditions for excitation of coherent states, which are assumed to be essential for normal biological activity. Malfunctioning mitochondria and disintegrated cytoskeleton result in disturbances of the Fröhlich's mechanism and consequently - together with biochemical disturbances - can lead to malignant properties of cancer cells.

... of PDH (pyruvate dehydrogenase) enzyme family (PDH converts pyruvate to acetyl CoA). DCA ...

• Neural Network World; International Journal on Neural and Mass - Parallel Computing and Information Systems
• Band 19 Nr. 4, Juli 2009

• Fröhlich's Physical Theory of Cancer - Fröhlich's Path From Theoretical Physics to Biology, and the Cancer Problem

A review is given of Fröhlich's approach to biology from the side of theoretical physics, and illustrated in the context of his prediction of three types of coherent excitations in living systems based on their dielectric and elastic properties and far-from-equilibrium (non-linear) character. Supporting experimental evidence is presented, and the difficulty in achieving reproducibility addressed. His envisaged role of coherent excitations in cell division and its control is outlined, together with the implications for cancer - as understood at the time of his work.

... thermal equilibrium by their metabolic activity, whence coherence might here be reasonably expecte... the specificity of the attraction between enzymes and their substrates, as well as the pairing of ho...

• Neural Network World; International Journal on Neural and Mass - Parallel Computing and Information Systems
• Band 19 Nr. 4, Juli 2009