Summary
Cell-mediated immunity (CMI) response of healthy humans and cancer (Ca) patients to specific tumor antigen and nonspecific (LDV - lactate dehydrogenase virus) antigen, and of acute myocardial infarction (AMI) and schizophrenia (Sch) patients to nonspecific antigen was investigated. Large differences of CMI response of healthy humans in comparison with Ca, AMI, Sch patients were found. CMI response to antigens displays transferred information about cells under immune surveillance. LDV disturbs the oxidative energy production system. We assume that CMI response to LDV antigen monitors pathological states of mitochondrial energy production which results in disturbances of electromagnetic activity of living cells.
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Extract
Mitochondrial Dysfunction
1. Introduction
Cell-mediated immunity (CMI) is understood to correlate with adherence properties of leukocytes (from peripheral blood). LAI (leukocyte adherence inhibition) assay is a quantitative technique that was widely used to study and monitor the CMI [1-5]. The LAI assay is based on observation of in vitro adherence of leukocytes to surfaces of glass or some plastic materials in the presence and in the absence of antigens. CMI response to antigens is related to specific processes in cells which are under immune surveillance and, therefore, displays transferred information about their state and evolution. But the LAI assay method is complex and tedious, and unequivocal results are conditioned by high purity of antigens used (i.e. the most immunoactive components have to be separated), and by experienced visual microscopic evaluation....See the full content of this document
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