Summary
Experimental studies have shown a symmetry-to-asymmetry transition of the spike-timing dependent plasticity (STDP) curve exists in the proximal stratum radiatum (SR) dendrite of the hippocampal CA1 pyramidal neuron, which is probably due to the presence of GABAergic inhibition [2, 3, 4]. A recent computational model predicted that symmetry-to-asymmetry transition is strongly dependent on the frequency and conductance value of GABA inhibition and that the largest long term potentiation (LTP) value and the two distinct long-term depression (LTD) tails of the symmetrical STDP curve are centred at +10 ms, +40 ms and -10 ms, respectively [8, 9]. In the present paper, we continue to investigate even further via computer simulations the effects of gamma frequency inhibition and its conductance value to the symmetry-to-asymmetry transition of the STDP profile in the SR dendrite and predict that the transition is even more robust when there is a temporal offset between the onsets of the pre-post excitatory stimulation and the GABAergic inhibition. The largest LTP value and the two distinct LTD tails are inversely proportional to the increase of GABA conductance.
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Extract
Modelling the Stdp Symmetry-to-Asymmetry Transition in the Presence of Gabaergic Inhibition
1. Introduction
Hebb's law of synaptic plasticity states that a synapse is strengthened only if the pre- and post-synaptic neurons are activated simultaneously [I]. Spike-timing dependent plasticity (STDP) is a physiologically relevant form of Hebbian plasticity, where the direction and extent of synaptic modification depends critically on the relative timing of pre- and postsynaptic action potentials or spikes [14]. Bi and Poo [7] showed that the profile of the STDP curve in the in-vitro hippocampal network has an asymmetrical shape with the largest LTP/LTD value at ?t = ï...See the full content of this document
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